We applied machine learning to the unmet medical need of rapid and accurate diagnosis and prognosis of acute infections and sepsis in emergency departments. Our solution consists of a Myrna (TM) Instrument and embedded TriVerity (TM) classifiers. The instrument measures abundances of 29 messenger RNAs in patient's blood, subsequently used as features for machine learning. The classifiers convert the input features to an intuitive test report comprising the separate likelihoods of (1) a bacterial infection (2) a viral infection, and (3) severity (need for Intensive Care Unit-level care). In internal validation, the system achieved AUROC = 0.83 on the three-class disease diagnosis (bacterial, viral, or non-infected) and AUROC = 0.77 on binary prognosis of disease severity. The Myrna, TriVerity system was granted breakthrough device designation by the United States Food and Drug Administration (FDA). This engineering manuscript teaches the standard and novel machine learning methods used to translate an academic research concept to a clinical product aimed at improving patient care, and discusses lessons learned.

Multi-modal learning plays a crucial role in cancer diagnosis and prognosis. Current deep learning based multi-modal approaches are often limited by their abilities to model the complex correlations between genomics and histology data, addressing the intrinsic complexity of tumour ecosystem where both tumour and microenvironment contribute to malignancy. We propose a biologically interpretative and robust multi-modal learning framework to efficiently integrate histology images and genomics by decomposing the feature subspace of histology images and genomics, reflecting distinct tumour and microenvironment features. To enhance cross-modal interactions, we design a knowledge-driven subspace fusion scheme, consisting of a cross-modal deformable attention module and a gene-guided consistency strategy. Additionally, in pursuit of dynamically optimizing the subspace knowledge, we further propose a novel gradient coordination learning strategy. Extensive experiments demonstrate the effectiveness of the proposed method, outperforming state-of-the-art techniques in three downstream tasks of glioma diagnosis, tumour grading, and survival analysis. Our code is available at https://github.com/helenypzhang/Subspace-Multimodal-Learning.

Climate change is a pressing global issue that requires widespread efforts across disciplines to develop technologies capable of significantly reducing or eliminating greenhouse gas emissions. Large-scale adoption of renewable energy sources and electric mobility are expected to be the main drivers toward this goal. The success of this transition hinges on the efficient integration of these technologies into the existing electricity infrastructure, which requires lithium-ion batteries as a vital storage medium, capturing and storing excess energy during peak production periods for use during times of low production or high demand. This energy storage capability is pivotal in maintaining a stable and reliable grid, to mitigate the intermittent nature of generation and demand in these technologies. Such energy storage capabilities are essential for sustaining a stable and reliable grid, particularly in mitigating the intermittent nature inherent in the generation and demand patterns associated with these technologies.

Vision transformer-based methods are advancing the field of medical artificial intelligence and cancer imaging, including lung cancer applications. Recently, many researchers have developed vision transformer-based AI methods for lung cancer diagnosis and prognosis. This scoping review aims to identify the recent developments on vision transformer-based AI methods for lung cancer imaging applications. It provides key insights into how vision transformers complemented the performance of AI and deep learning methods for lung cancer. Furthermore, the review also identifies the datasets that contributed to advancing the field. Of the 314 retrieved studies, this review included 34 studies published from 2020 to 2022. The most commonly addressed task in these studies was the classification of lung cancer types, such as lung squamous cell carcinoma versus lung adenocarcinoma, and identifying benign versus malignant pulmonary nodules. Other applications included survival prediction of lung cancer patients and segmentation of lungs. The studies lacked clear strategies for clinical transformation. SWIN transformer was a popular choice of the researchers; however, many other architectures were also reported where vision transformer was combined with convolutional neural networks or UNet model. It can be concluded that vision transformer-based models are increasingly in popularity for developing AI methods for lung cancer applications. However, their computational complexity and clinical relevance are important factors to be considered for future research work. This review provides valuable insights for researchers in the field of AI and healthcare to advance the state-of-the-art in lung cancer diagnosis and prognosis. We provide an interactive dashboard on lung-cancer.onrender.com/.

The rapid development of diagnostic technologies in healthcare is leading to higher requirements for physicians to handle and integrate the heterogeneous, yet complementary data that are produced during routine practice. For instance, the personalized diagnosis and treatment planning for a single cancer patient relies on the various images (e.g., radiological, pathological, and camera images) and non-image data (e.g., clinical data and genomic data). However, such decision-making procedures can be subjective, qualitative, and have large inter-subject variabilities. With the recent advances in multi-modal deep learning technologies, an increasingly large number of efforts have been devoted to a key question: how do we extract and aggregate multi-modal information to ultimately provide more objective, quantitative computer-aided clinical decision making? This paper reviews the recent studies on dealing with such a question. Briefly, this review will include the (1) overview of current multi-modal learning workflows, (2) summarization of multi-modal fusion methods, (3) discussion of the performance, (4) applications in disease diagnosis and prognosis, and (5) challenges and future directions.

Healthcare digitalization requires effective applications of human sensors, when various parameters of the human body are instantly monitored in everyday life due to the Internet of Things (IoT). In particular, machine learning (ML) sensors for the prompt diagnosis of COVID-19 are an important option for IoT application in healthcare and ambient assisted living (AAL). Determining a COVID-19 infected status with various diagnostic tests and imaging results is costly and time-consuming. This study provides a fast, reliable and cost-effective alternative tool for the diagnosis of COVID-19 based on the routine blood values (RBVs) measured at admission. The dataset of the study consists of a total of 5296 patients with the same number of negative and positive COVID-19 test results and 51 routine blood values. In this study, 13 popular classifier machine learning models and the LogNNet neural network model were exanimated. The most successful classifier model in terms of time and accuracy in the detection of the disease was the histogram-based gradient boosting (HGB) (accuracy: 100%, time: 6.39 sec). The HGB classifier identified the 11 most important features (LDL, cholesterol, HDL-C, MCHC, triglyceride, amylase, UA, LDH, CK-MB, ALP and MCH) to detect the disease with 100% accuracy. In addition, the importance of single, double and triple combinations of these features in the diagnosis of the disease was discussed. We propose to use these 11 features and their binary combinations as important biomarkers for ML sensors in the diagnosis of the disease, supporting edge computing on Arduino and cloud IoT service.

Continuous diagnosis and prognosis are essential for intensive care patients. It can provide more opportunities for timely treatment and rational resource allocation, especially for sepsis, a main cause of death in ICU, and COVID-19, a new worldwide epidemic. Although deep learning methods have shown their great superiority in many medical tasks, they tend to catastrophically forget, over fit, and get results too late when performing diagnosis and prognosis in the continuous mode. In this work, we summarized the three requirements of this task, proposed a new concept, continuous classification of time series (CCTS), and designed a novel model training method, restricted update strategy of neural networks (RU). In the context of continuous prognosis, our method outperformed all baselines and achieved the average accuracy of 90%, 97%, and 85% on sepsis prognosis, COVID-19 mortality prediction, and eight diseases classification. Superiorly, our method can also endow deep learning with interpretability, having the potential to explore disease mechanisms and provide a new horizon for medical research. We have achieved disease staging for sepsis and COVID-19, discovering four stages and three stages with their typical biomarkers respectively. Further, our method is a data-agnostic and model-agnostic plug-in, it can be used to continuously prognose other diseases with staging and even implement CCTS in other fields.

Few know that Coronavirus and its allied disease Covid-19 was first discovered by a data-mining program. HealthMap, a website run by Boston Children's Hospital, raised an alarm about multiple cases of pneumonia in Wuhan, China, rating its urgency at three on a scale of five. As it progressed, Governments struggled to deal with the unprecedented crisis on multiple fronts and were forced to look at innovative ways to augment their efforts; presenting an opportunity to leverage Artificial Intelligence (AI). AI was used in varied settings including drug discovery, testing, prevention and overcoming resource constraints, and its success opened a whole new door of possibilities. Here's a look at some of the most intuitive, innovative and advantageous uses of the technology during COVID-19, outlined under the four categories of diagnosis and prognosis, prediction and tracking, patient care and drug development: In Xinchang County, China, the drones delivered medical supplies to centers in need, and thermal sensing drones 14 identified people running fever, potentially infected with the virus.

Purpose: To utilize high-resolution quantitative CT (QCT) imaging features for prediction of diagnosis and prognosis in fibrosing interstitial lung diseases (ILD). Approach: 40 ILD patients (20 usual interstitial pneumonia (UIP), 20 non-UIP pattern ILD) were classified by expert consensus of 2 radiologists and followed for 7 years. Clinical variables were recorded. Following segmentation of the lung field, a total of 26 texture features were extracted using a lattice-based approach (TM model). The TM model was compared with previously histogram-based model (HM) for their abilities to classify UIP vs non-UIP. For prognostic assessment, survival analysis was performed comparing the expert diagnostic labels versus TM metrics. Results: In the classification analysis, the TM model outperformed the HM method with AUC of 0.70. While survival curves of UIP vs non-UIP expert labels in Cox regression analysis were not statistically different, TM QCT features allowed statistically significant partition of the cohort. Conclusions: TM model outperformed HM model in distinguishing UIP from non-UIP patterns. Most importantly, TM allows for partitioning of the cohort into distinct survival groups, whereas expert UIP vs non-UIP labeling does not. QCT TM models may improve diagnosis of ILD and offer more accurate prognostication, better guiding patient management.

We included 13 studies on machine learning-based prediction models in IBD encompassing themes of predicting treatment response to biologics and thiopurines, predicting longitudinal disease activity and complications and outcomes in patients with acute severe ulcerative colitis. The most common machine learnings models used were tree-based algorithms, which are classification approaches achieved through supervised learning. Machine learning models outperformed traditional statistical models in risk prediction. However, most models were at high risk of bias, and only one was externally validated.